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KMID : 1033520150060010065
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Korean Society of Medical Sonographers
2015 Volume.6 No. 1 p.65 ~ p.78
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Comparative Study of Transient Elastography and liver biopsy in diagnosing liver fibrosis
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Kim Hyeon-Jin
Lee Won-Hong
Jin Mi-Kyeong
Suh Dae-Keon
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Abstract
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Purpose: Transient elastography by analyzing the results of liver fibrosis and liver biopsy to evaluate the results with accuracy and usefulness of the TE for diagnosing liver fibrosis.
Materials and Methods: 304 patients who underwent biopsies before and after the TE among patients who underwent liver fibrosis confirmed by liver biopsy between approximately August 2013 to August 2014 was a retrospective analysis in this study. Liver biopsy on the basis of the results presented in liver tissue technical instructions for Pathology F0, F1, F2, F3, divided into steps of F4. TE uses Fibroscan F2≥, 7.2 kPa; F3≥, 9.6 kPa; F = 4, were separated by 14.5 kPa step. Statistical analysis SPSS ver. 18.0 was processed using the software for, the P-value for each statistical significance level was defined as less than 0.05.
Results: The sensitivity of the TE to cirrhosis of the liver also is 94.80%, a specificity of 77.08%, 90.95% accuracy, positive predictive value of 93.71% and the negative predictive value was 80.43%. Approximate 95% confidence interval of the TE is 0.933, cut-off value was 0.859 at 0.786, respectively approximate significance probability of TE was 0.000(p<0.05). Match measure kappa value 0.730, 0.000, significant probability of two diagnostic methods was found to have a significant correspondence (p<0.05).
Conclusion: cirrhosis of liver biopsy is also used in the diagnosis of invasive methods such side effects occur in the course of representation issues and biopsy diagnosed with cirrhosis of liver, some organizations only. Therefore, the correspondence with TE looks to cirrhosis of the liver biopsy results also think that it would be more effective to use a substitute measure.
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KEYWORD
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fibroscan, fibrosis, Liver biopsy, Transient elastography
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